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The undeclared active pharmaceutical ingredients in some of these products include sibutramine (a controlled substance), rimonabant ( a drug not approved for marketing in the United States), phenytoin ( an anti-seizure medication), and phenolphthalein (a solution used in chemical experiments and a suspected cancer causing agent). Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs Advisory Committee did not recommend approval of rimonabant (Zimulti / Accomplia) to the US FDA. "If one is using rimonabant, patients should be monitored carefully for the emergence of depressive symptoms and/or suicidal thoughts," he added. A CB1 antagonist called rimonabant is currently marketed overseas for weight loss. Effect of Rimonabant on Body Weight and the Metabolic Syndrome in Overweight Patients. Rimonabant is not yet approved for use in the United States, where it is known as Zimulti.
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