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The addition of allopurinol may help to protect the renal tubules from long-term damage due to uric acid crystallization. {06} {35} {36} However, the uricosuric agents are less toxic than allopurinol and should be considered for use when appropriate {37}. Ask your health care provider if Allopurinol may interact with other medicines that you take. Allopurinol will help prevent gout attacks only as long as you continue to take it. The following information includes only the average doses of allopurinol. The mechanism is unknown and pharmacokinetic studies with hydrochlorothiazide have not demonstrated any effects on the disposition of allopurinol or oxipurinol (its major metabolite).

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