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Brand name: prilocaine
Generic name: emla, Lidocaine, prilocaine, pain
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Very young children (less than 1 year of age) may be especially sensitive to the effects of lidocaine and prilocaine. 5% is a microemulsion in which the oil phase is a eutectic mixture of lidocaine and prilocaine in a ratio of 1:1 by weight. In a study in adults, there was no difference between prilocaine and articaine in providing successful anesthesia of mandibular pulpal and lingual soft tissue and of maxillary palatal soft tissue with buccal infiltration. Lack of differential effect by Ultracaine (Articaine) and Cinatest (Prilocaine) in infiltration anesthesia. The prilocaine metabolite o-toluidine and the hydroxylated metabolites of o-toluidine are excreted mainly in the urine. Both lidocaine and prilocaine block sodium ion channels required for the initiation and conduction of neuronal impulses, resulting in local anesthesia.

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